Motor neuron disease (MND) is a group of chronic progressive neurodegenerative diseases with unknown etiological factors, including spinal cord anterior horn cells, brainstem motor neurons, cortical pyramidal cells and pyramidal tract. The incidence is about 1 / 3 / 100, 000 a year, and the prevalence is 4 / 8 / 100, 000 a year. As most patients die within 3 to 5 years after symptoms, the prevalence and incidence of the disease are close to. MND etiology is not clear. It is generally believed that with age, the disease is caused by the genetic susceptibility individuals exposed to adverse environment. That is, genetic factors and environmental factors together led to the occurrence of motor neuron disease.
According to a large number of epidemiological surveys, many environmental factors associated with ALS disease have been found, including heavy metals, pesticides, herbicides, trauma, diet, and exercise. However, in general, there is a lack of association between these factors, and whether they are associated with the occurrence of ALS and their mechanisms for the occurrence of ALS are also needed. It is further confirmed that the environmental factors associated with ALS are mainly agricultural and rural life, electrical injury, ionizing radiation, trauma, excessive exercise, smoking, industrial materials, heavy metals and so on.< RETURN