Name: Mr. Wang
Diagnosis: Alcoholic Cirrhosis
Therapy: Stem Cell Therapy
Condition before Stem Cell Transplantation for Liver Cirrhosis
Mr. Wang is a 46-year old male from China with a history of alcoholic cirrhosis of the liver for more than 10 years. On January 25th 2010, he received his treatment. For over 20 years, Mr. Wang had suffered from substance abuse of tobacco and alcohol. He also suffered from dietary deficiencies in this time frame, and was under nourished. Further, Mr. Wang was also diagnosed with type-2 diabetes in 1998. He also suffered from intermittent abdominal distension, secondary to ascites from his cirrhotic liver. These multiple and inter-related conditions had lasted for more than nine years.
Mr. Wang’s condition was unstable. In September 2000, he had been sent to his local hospital with an episode of hematemesis (vomiting 1200cc of blood), following drinking a large quantity of alcohol. At this time, he was diagnosed with alcoholic cirrhosis, portal hypertension (PHT), abdominal ascites and upper gastrointestinal bleeding (UGB) (all conditions secondary to his liver disease).
By using some medications, blood transfusion and other modalities, the gastrointestinal bleeding was brought under control. His history of drinking continued, and the gastrointestinal bleeding occurred repeatedly, each with estimated volume of blood: 300 – 400ml.
On April 20th 2001, he underwent a procedure of portal vein embolization for his esophagus varicosities in the interventional radiology department of No.301 Army Hospital of China. There was no further gastrointestinal bleeding. However, the intermittent abdominal distension (secondary to his liver failure) remained after this procedure.
In 2006, he received an operation of splenectomy, due to hypersplenia/splenic hypertrophy. In November 2009, an abdominal ultrasound was taken. It revealed that there was massive abdominal ascites, which was as deep as 12cm. The abdominal ascites was partially relieved with medication, but it reoccurred again within two months. He began to suffer mental symptoms as well.
He was conscious when admitted, but with poor spirit. He felt fatigued, due in part to his poor quality of sleep. His temper was frayed. His appetite was poor, and he was symptomatic with his ascites. Test results showed that blood ammonia and serum glutamic oxaloacetic transaminase (SGOT) were high. His blood ammonia was as much higher than normal: 152umol/L (Normal Range: 9.0 – 33.0umol/L). He needed to be restricted on his intake of protein because of the ammonia, and the degree of his hepatic cirrhosis was severe.
Approach and Procedure
Stem cell transplantation for Alcoholic Cirrhosis
Condition after Stem Cell Transplantation for Liver Cirrhosis
Within several days after the stem cell transplantation treatment, Mr. Wang felt a great improvement in his mental spirit. Unlike the frequent feeling of fatigue, his mental spirit improved. His blood ammonia had decreased from 152umol/L down to 35umol/L, just outside normal range. This was a most remarkable improvement in his medical condition.
As the treatment continued, his abdominal distension (secondary to his ascites) was greatly relieved and reduced. He had improved sleep quality and increased appetite.
Mr. Wang was very satisfied with the effects of the stem cell treatment. After completing the first treatment he went on to complete interventional stem cell therapy two months later in order to consolidate the effects and to improve the liver function towards a full recovery.