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Cell-based Gene Therapy for Thromboangiitis Obliterans, Mr. Wu from China

Name: Mr. Wu
Age: 30
Gender: Male
Nationality: China
Diagnosis: Thromboangiitis Obliterans
Therapy: Cell-based gene therapy (HGF and adipose-derived stem cells)

Conditions before Cell-based Gene Therapy for Thromboangiitis Obliterans

Mr. Wu is a 30 years old patient suffered from thromboangiitis obliterans for more than a half decade. He was a veteran from China Armed Forces. Besides being a heavy smoker, Mr. Wu had a healthy lifestyle. He was able to smoke more than two dozens of cigarettes per day. Although his wife has urged him to stop such habit, but Mr. Wu experienced a hard time when he tried giving up smoking even for a week. Such habit has severely affected his feet as any ulceration was hard to recover, even a minor injury required few months to heal. Mr. Wu also experienced coldness on his lower limbs even during summer. He could feel dull pain in his lower limbs from time to time. In the physical examination of his medical report, his feet presented with purple color when he lifted up his feet. Weak pulse of dorsalis pedis artery was also noted. Amputation was recommended by the doctor if the condition continued to deteriorate.

Therapy and Procedure

Cell-based gene therapy (HGF and adipose-derived stem cells): 3 intramuscular injections

Conditions after Cell-based Gene Therapy for Thromboangiitis Obliterans

Seven weeks after cell-based gene therapy for his thromboangiitis obliterans, evident improvements happened. He gains more strength on his lower limbs, which brings more convenience to his life. There is no dull pain or cold feeling in his feet anymore. The occurrence of ulceration reduces obviously and the minor injury is easier and quicker to be healed now as well (usually one to two weeks). When examined, the pulse of his dorsalis pedis artery is stronger and powerful compared with prior condition.

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